Luis Del Valle MD

Luis Del Valle MD

Associate Professor of Pathology Associate Professor of Medicine (Hematology/Oncology)


M.D. - Universidad Nacional Autónoma de México, México D.F. México

Residency and Fellowships

Residency: Pathology, Hospital General de México & Universidad Nacional Autónoma de México, México D.F. México

Post-doctoral Fellowship: Neuropathology, Thomas Jefferson University, Philadelphia, Pennsylvania USA

Post-doctoral Fellowship: Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania USA

Research Interests

Polyomaviruses (JCV, Merkel Cell Polyomavirus)

Progressive Multifocal Leukoencephalopathy

Glial Brain Tumors


Viral Oncogenesis

DNA Damage and Repair mechanisms

Lab Members

Amanda Parker Struckhoff, Ph.D.    (Post-Doctoral Fellow)

Jimena Trillo-Tinoco, M.D.              (Post-Doctoral Fellow)

Michale Ripple                                (Graduate Student)

Teaching Activities

Pathology 200 Course (LSU School of Medicine)

Neuropathology I: Introduction to Neuropathology

Neuropathology IV: Cerebro-Vascular diseases

Neuropathology V: Demyelinating diseases

Neuropathology VI: Neuro-Degenerative diseases

Neuropathology VII: Brain Tumors

Selected Publications

10209983.   Khalili K, Krynska B, Del Valle L, Katsetos CD, and Croul S. (1999).  Medulloblastomas and the human neurotropic polyomavirus JC virus.  Lancet; 353 (9159): 1152-1153

10500209.   Krynska B, Del Valle L, Croul S, Gordon J, Katsetos CD, Carbone M, Giordano A, and Khalili K. (1999).  Detection of human neurotropic JC virus DNA sequences and expression of the viral oncogenic protein in pediatric medulloblastomas.  Proceedings of the National Academy of Sciences USA; 96 (20): 11,519-11,524

10602409.   Bonvetch R, Croul S, Richardson MW, Lorenzana C, Del Valle L, Alexander GM, Amini S, Morgello S, Khalili K, and Rappaport J. (1999). Role of HIV-1 Tat and CC chemokine MIP-1 a in the pathogenesis of HIV associated Central Nervous System disorders.  Journal of NeuroVirology; 5 (6): 685-694

10878711.   Del Valle L, Croul S, Morgello S, Amini S, Rappaport J, and Khalili K. (2000).  Detection of HIV-1 Tat and JCV capsid protein, VP1, in AIDS brain with Progressive Multifocal Leukoencephalopathy.  Journal of Neurovirology; 6 (3): 221-228

10936089.   Krynska B, Del Valle L, Gordon J, Otte J, Croul S, and Khalili K. (2000). Identification of a novel p53 mutation in JCV-induced mouse Medulloblastoma.  Virology; 274 (1): 65-74

11039901.   Gordon J, Del Valle L, Otte J, and Khalili K. (2000). Pituitary neoplasia induced by expression of human neurotropic Polyomavirus, JCV, early genome in transgenic mice.  Oncogene; 19 (42): 4840-4846

11117551.   Del Valle L, Azizi A, Krynska B, Enam S, Croul S, and Khalili K. (2000).  Reactivation of human neurotropic JC virus expressing oncogenic protein, in a recurrent Glioblastoma multiforme.  Annals of Neurology; 48 (6): 932-936

11358858.   Del Valle L, Gordon J, Assimakopoulou M, Katsetos CD, Geedes J, Varakis JN, Croul S, and Khalili K. (2001).  Detection of JC virus DNA sequences and expression of the viral regulatory protein T-Antigen in tumors of the central nervous system.  Cancer Research; 61 (10): 4287-4293

11577176.   Del Valle L, Behring J, Lorenzana C, Giordano A, Khalili K, and Croul S. (2001).  Expression of a polyoma virus oncoprotein and tumor suppressor proteins in medulloblastomas.  Journal of Clinical Pathology; Molecular Pathology; 54 (5): 331-337

11854388.   Del Valle L, Gordon J, Enam S, Delbue S, Croul S, Abraham S, Radhakrishnan S, Assimakopoulou M, Katsetos CD, and Khalili K. (2002).  Expression of human neurotropic polyomavirus JCV late gene product Agnoprotein in human medulloblastoma.  Journal of the National Cancer Institute; 94 (4): 267-273

11877394.   Lassak A, Del Valle L, Peruzzi F, Wang JY, Croul S, Khalili K, and Reiss K. (2002).  Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen.  Journal of Biological Chemistry; 277 (19): 17,231-17,238

11914404.   Del Valle L, Delbue S, Gordon J, Enam S, Croul S, Ferrante P, and Khalili K. (2002).  Expression of JC virus T-Antigen in a multiple sclerosis patient with a Glioblastoma multiforme.  Neurology; 58 (6): 895-900

12060623.   Del Valle L, Enam S, Lassak A, Wang JY, Croul S, Khalili K, and Reiss K. (2002).  Insulin-like Growth Factor 1 receptor activity in human medulloblastomas.  Clinical Cancer Research; 8 (6): 1822-1830

12429619.   Del Valle L, Enam S, Lara C, Ortiz-Hidalgo C, Katsetos CD, and Khalili K. (2002).  Detection of JC polyomavirus DNA sequences and cellular localization of T-Antigen and Agnoprotein in oligodendrogliomas.  Clinical Cancer Research; 8 (11): 3332-3340

12471454.   Katsetos CD, Del Valle L, Legido A, deChadarévian JP, Geddes JF, and Mörk SJ. (2003).  On the neuroblastic nature of cerebellar Medulloblastomas: a tribute to Pio del Rio Hortega and Moises Polak.  Acta Neuropathologica (Berlin); 105 (1): 1-13

14987161.   Enam S, Sweet T, Amini S, Khalili K, and Del Valle L. (2004).  Evidence for involvement of transforming growth factor beta1 signaling pathway in activation of JC virus in human immunodeficiency virus 1-associated Progressive Multifocal Leukoencephalopathy.  Archives of Pathology and Laboratory Medicine; 128 (3): 282-291

15016869.   Del Valle L, Enam S, Lara C, Miklossy J, Khalili K, and Gordon J. (2004).  Primary central nervous system lymphoma expressing the human neurotropic polyomavirus, JC virus genome.  Journal of Virology; 78 (7): 3462-3469

15133494.   Shollar D, Del Valle L, Khalili K, and Gordon J. (2004).  JCV T-antigen interacts with the neurofibromatosis type 2 gene product in a transgenic mouse model of malignant peripheral nerve sheath tumor.  Oncogene; 23 (32): 5459-5467

15195141.   Rao G, Pedone CA, Del Valle L, Reiss K, Holland EC, and Fults DW. (2004).  Sonic hedgehog and Insulin-like Growth Factor signaling synergize to induce Medulloblastoma formation from nestin-expressing neural progenitors in mice.  Oncogene; 23 (36): 6156-6162

15965906.   Trojanek J, Ho T, Del Valle L, Wang JY, Darbinyan A, Nowicki M, Croul S, Skorski T, Khalili K, and Reiss K. (2006).  T-antigen from human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51.  Journal of Cell Physiology; 206 (1): 35-46

16146764.   Del Valle L, and Piña-Oviedo S. (2005).  HIV disorders of the brain; pathology and pathogenesis.  Frontiers in Bioscience; 11: 718-732

16557392.   Piña-Oviedo S, Enam S, De León-Bojorque B, Cuesta-Mejías T, Ortiz-Hidalgo C, White M, Khalili K, and Del Valle L. (2006).  Glioblastoma multiforme with small cell neuronal-like component: association with human neurotropic JC virus.  Acta Neuropathologica (Berl); 111 (4): 388-396

16611822.   Aprea S, Del Valle L, Mameli G, Sawaya BE, Khalili K, and Peruzzi F. (2006).  Tubulin-mediated binding of human immunodeficiency virus-1 Tat to the cytoskeleton causes proteasomal dependent-degradation of microtubule-associated protein 2 and neuronal damage.  Journal of Neuroscience; 26 (15): 4054-4062

17368705.   Darbinyan A, White MK, Akan S, Radhakrishnan S, Del Valle L, Amini S, and Khalili K. (2007). Alterations of DNA damage repair pathways resulting from JCV infection.  Virology; 364 (1): 73-86

17392168.   Piña-Oviedo S, Urbanska K, Radhakrishnan S, Sweet T, Reiss K, Khalili K, and Del Valle L. (2007). Effects of JC Virus Infection on Anti-Apoptotic Protein Survivin in Progressive Multifocal Leukoencephalopathy. American Journal of Pathology; 170 (4): 1291-1304

17851187.   Woodruff-Pak DS, Agelan A, and Del Valle L. (2007).  A rabbit model of Alzheimer’s disease: valid at neuropathological, cognitive, and therapeutic levels.  Journal of Alzheimer’s Disease; 11 (3): 371-383

18688812.   Perez-Liz G, Del Valle L, Gentilella A, Croul S, and Khalili K. (2008). Detection of JC Virus DNA fragments but not proteins in normal brain tissue.  Annals of Neurology; 64 (4): 379-387

18786633.   Del Valle L, Schwartzman RJ, and Alexander G. (2009). Spinal cord histopathological alterations in a patient with longstanding Complex Regional Pain Syndrome.  Brain, Behavior, and Immunity; 23 (1): 85-91

19117011.   Urbanska K, Pannizzo P, Lassak A, Gualco E, Surmacz E, Croul S, Del Valle L, Khalili K and Reiss K. (2009). Estrogen Receptor b-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in Medulloblastoma.  Journal of Cellular Physiology; 219 (2): 392-401

19204000.   Deshmane SL, Mukerjee R, Fan S, Del Valle L, Michiels C, Sweet T, Rom I, Khalili K, Rappaport J, Amini S, and Sawaya BE. (2009). Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of Hypoxia Inducible Factor 1 alpha expression.  Journal of Biological Chemistry; 284 (17): 11,364-11,373

19335536.   Piña-Oviedo S, Del Valle L, Baquera-Heredia J, and Ortiz-Hidalgo C. (2009). Immunohistochemical characterization of Renaut bodies in superficial digital nerves: further evidence supporting their perineural cell origin.  Journal of the Peripheral Nervous System; 14 (1): 22-26

19360424.   Piña-Oviedo S, Khalili K, and Del Valle L. (2009). Hypoxia Inducible Factor-1 alpha activation of the JCV promoter: role in the pathogenesis of Progressive Multifocal Leukoencephalopathy.  Acta Neuropathologica (Berl); 118 (2): 235-247

19775291.   Riolfi M, Ferla R, Del Valle L, Piña-Oviedo S, Scolaro L, Micciolo R, Guidi M, Terrasi M, Cetto GL, and Surmacz E. (2010).  Leptin and its Receptor are overexpressed in Brain Tumors and correlate with the degree of malignancy.  Brain Pathology; 20 (2): 481-489

19834489.   Gualco E, Urbanska K, Perez-Liz G, Sweet T, Peruzzi F, Reiss K, and Del Valle L. (2010). IGF-1R dependent activation of Survivin is required for T-Antigen mediated protection from apoptosis and proliferation of neural progenitors.  Cell Death & Differentiation; 17 (3): 439-451

20181935.   Rom I, Rom S, Passiatore G, Pacifici M, Radhakrishnan S, Del Valle L, Piña-Oviedo S, Khalili K, Eletto D, and Peruzzi F. (2010). CCL8/MCP2 is a target for mir-146a in HIV-1 infected human microglial cells. FASEB Journal; 24 (7): 2292-2300

20190567.   Del Valle L, Piña-Oviedo S, Perez-Liz G, Augelli BJ, Azizi A, Khalili K, Gordon J, and Krynska B. (2010). Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics.  Cancer Biology & Therapy; 9 (4): 286-297

20336718.   Del Valle L, and Khalili K. (2010). Detection of JC virus proteins, T-Antigen and Agnoprotein in human tumor tissue arrays.  Journal of Medical Virology; 82 (5): 806-811

20631174.   Ramirez SH, Fan S, Dykstra H, Reichenbach N, Del Valle L, Potula R, Phipps RP, Maggirwar SB, and Persidsky Y. (2010). Dyad of CD40/CD40 ligand fosters neuroinflammation at the blood-brain barrier and is regulated via JNK signaling: Implications for HIV-1 Encephalitis.  Journal of Neuroscience; 30 (28): 9454-9464

21088492.   Mukerjee R, Claudio PP, Chang JR, Del Valle L, and Sawaya BE. (2010). Transcriptional regulation of HIV-1 gene expression by p53.  Cell Cycle; 9 (22): 4569-4578

21115295.   Langford D, Baron D, Joy J, Del Valle L, and Shack J. (2011). Contributions of HIV infection in the hypothalamus and substance abuse/use to HPT dysregulation.  Psychoneuroendocrinology; 36 (5): 710-719

21561597.   Festa M, Del Valle L, Khalili K, Franco R, Scognamiglio G, Graziano V, De Laurenzi V, Turco MC, and Rosati A. (2011). BAG3 protein is overexpressed in human Glioblastoma and is a potential target for therapy.  American Journal of Pathology; 178 (6): 2504-2512

21745501.   Rom S, Pacifici M, Pasiatore G, Aprea S, Waligorska A, Del Valle L, and Peruzzi F. (2011). HIV-Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction. BBA: Molecular Cell Research; 1813 (10): 1836-1844

21816823.   Mukerjee R, Chang JR, Del Valle L, Bagashev A, Gayed MM, Lyde RB, Hawkins BJ, Brailoiu E, Cohen E, Power C, Azizi AS, Gelman BB, and Sawaya BE. (2011). Deregulation of microRNAs by HIV-1 Vpr leads to the development of neurocognitive disorders.  Journal of Biological Chemistry; 286 (40): 34,976-34,985

21956116.   Chang R, Mukerjee R, Del Valle L, Bagashev A, Hawkins BJ, and Sawaya BE. (2011).  HIV-1 Tat promotes neuronal dysfunction through disruption of microRNAs.  Journal of Biological Chemistry; 286 (47): 41,125-41,134

23260029.   Dela Cruz FN, Giannitti F, Li L, Woods LW, Del Valle L, Delwart E, and Pesavento PA. (2012).  Novel Polyomavirus associated with Brain Tumors in Free-Ranging Raccoons, Western United States.  Emerging Infectious Diseases; 19 (1): 77-84

LCRC Faculty

Missy Wooley
Population Sciences
Louisiana Tech University
Asim Abdel-Mageed DVM PhD
Therapeutics & Diagnostics
Tulane University School of Medicine
Ramsy Abdelghani, MD
Therapeutics & Diagnostics
Tulane University School of Medicine
Jiri Adamec, PhD
Therapeutics & Diagnostics
LSU Health - New Orleans
Sara Al-Dahir, PharmD, PhD, MPH
Population Sciences
Xavier University
Suresh K. Alahari PhD
Therapeutics & Diagnostics
LSU Health - New Orleans
Ashad Alam, MD, PhD
Tumor Biology
Ochsner Health
Muralidharan Anbalagan, PhD
Therapeutics & Diagnostics
Tulane University School of Medicine
Wayne L. Backes PhD
Tumor Biology
LSU Health - New Orleans