Thomas Wiese PhD

Thomas Wiese PhD


Thomas Wiese, Ph.D. is a professor in the Department of Basic Pharmaceutical Sciences and is LCRC Associate Director of Cancer Research Training. Dr. Wiese is the Xavier Associate Director of the LCRC. His office is located in room 309 COP.


Dada SN, Babanyinah GK, Tetteh MT, Palau VE, Walls ZF,Krishnan K, Croft Z, Khan AU, Liu G, Wiese TE, Glotser E, Mei H (2022) Covalent and Noncovalent Loading ofDoxorubicin by Folic Acid-Carbon Dot Nanoparticles for Cancer Theranostics. Acs Omega Vol. 7, No. 27, pp.23322-23331

Yanagihara R, Berry MJ, Carson MJ, Chang SP, CorlissH, Cox MB, Haddad G, Hohmann C, Kelley ST, Lee ESY, Link BG, Noel RJ, Jr.,Pickrel J, Porter JT, Quirk GJ, Samuel T, Stiles JK, Sy AU, Taira DA, Trepka MJ, Villalta F, Wiese TE (2021) Building a Diverse Workforce and Thinkforce to Reduce Health Disparities. International Journal of EnvironmentalResearch and Public Health Vol. 18, No. 4, pp. 1569

Guo S, Zhang C, Bratton M, Mottamal M, Liu J, Ma P,Zheng S, Zhong Q, Yang L, Wiese T, Wu Y, Ellis M, Matossian M, Burow M, MieleL, Houtman R, Wang G (2018) ZB716, aSteroidal Selective Estrogen Receptor Degrader (SERD), is Orally Efficacious inBlocking Tumor Growth in Mouse Xenograft Models. Oncotarget Vol. 9, pp. 6924-6937

Liu J, Zheng S, Guo S, Zhang C, Zhong Q, Zhang Q, MaP, Skripnikova EV, Bratton MR, Wiese TE, Wang G (2017) Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator. ACS Medicinal Chemistry Letters Vol. 8, No. 1, pp. 102-106

Liu J, Zheng S, Akerstrom VL, Yuan C, Ma Y, Zhong Q,Zhang C, Zhang Q, Guo S, Ma P, Skripnikova EV, Bratton MR, Pannuti A, Miele L,Wiese TE, Wang G (2016) Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD). Journal ofMedicinal Chemistry Vol. 59, No. 17, pp. 8134-8140

Liu J, Pham PT, Skripnikova EV, Zheng S, Lovings LnJ,Wang Y, Goyal N, Bellow SM, Mensah LM, Chatters AJ, Bratton MR, Wiese TE, Zhao M, Wang G, Foroozesh M (2015) ALigand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2. Journal of Medicinal Chemistry Vol. 58, No. 16, pp. 6481-6493

Bratton MR, Martin EC, Elliott S, Rhodes LV, Collins-Burow BM, McLachlan JA, Wiese TE, Boue SM, Burow ME (2015) Glyceollin, a novel regulator of mTOR/p70S6 in estrogen receptorpositive breast cancer. Journal OfSteroid Biochemistry And Molecular Biology Vol. 150, pp. 17-23


Wells K, Lima D, Meade C, Muñoz-Antonia T, Scarinci I,McGuire A, Gwede C, Pledger W, Partridge E, Lipscomb J, Matthews R, Matta J,Flores I, Weiner R, Turner T, Miele L, Wiese T, Fouad M, Moreno C, Lacey M,Christie D, Price-Haywood E, Quinn G, Coppola D, Sodeke S, Green B, LichtveldM, investigators obotRGB (2013) Assessing Needs and Assets for Building a Regional Network Infrastructure to Reduce Cancer Related Health Disparities. EvalProgram Plann Vol. 44C, pp. 14-25

Cao B, Liu XC, Li J, Liu S, Qi YF, Xiong ZG, Zhang A,Wiese T, Fu XQ, Gu JK, Rennie PS, Sartor O, Lee BR, Ip C, Zhao LJ, Zhang HT,Dong Y (2013) 20(S)-protopanaxadiol-aglycone downregulation of the full-length and splice variants of androgen receptor.International Journal of Cancer Vol.132, No. 6, pp. 1277-1287

Bratton MR, Frigo DE, Segar HC, Nephew KP, McLachlanJA, Wiese TE, Burow ME (2012) The Organochlorine o,p '-DDT Plays a Role in Coactivator-Mediated MAPK Crosstalk in MCF-7 Breast Cancer Cells. EnvironmentalHealth Perspectives Vol. 120, No. 9, pp. 1291-1296

Tilghman SL, Bratton MR, Segar HC, Martin EC, RhodesLV, Li M, McLachlan JA, Wiese TE, Nephew KP, Burow ME, Collins BM (2012) Endocrine Disruptor Regulation of MicroRNAExpression in Breast Carcinoma Cells. PLoSONE Vol. 7, No. 3,

Schenck K, Rosenblum L, Wiese TE, Wymer L, Dugan N,Williams D, Mash H, Merriman B, Speth T (2012) Removal of estrogens and estrogenicity through drinking water treatment. Journal of Water and Health Vol. 10,No. 1,

Khupse RS, Sarver JG, Trendel JA, Bearss NR, Reese MD,Wiese TE, Boue SM, Burow ME, Cleveland TE, Bhatnagar D, Erhardt PW (2011) Biomimetic Syntheses and Antiproliferative Activities of Racemic, Natural (-), and Unnatural (+) Glyceollin I. Journal of Medicinal Chemistry Vol. 54,No. 10, pp. 3506-3523

Antoon JW, Meacham WD, Bratton MR, Slaughter EM,Rhodes LV, Ashe HB, Wiese TE, Burow ME, Beckman BS (2011) Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer. Journal of Molecular Endocrinology Vol. 46, No. 3, pp. 205-216

Boue SM, Burow ME, Wiese TE, Shih BY, Elliott S,Carter-Wientjes CH, McLachlan JA, Bhatnagar D (2011) Estrogenic and Antiestrogenic Activities of Phytoalexins from RedKidney Bean (Phaseolus vulgaris L.). Journal of Agricultural & Food Chemistry Vol. 59, No. 1, pp. 112-120

Antoon JW, White MD, Meacham WD, Slaughter EM, MuirSE, Elliott S, Rhodes LV, Ashe HB, Wiese TE, Smith CD, Burow ME, Beckman BS(2010) Antiestrogenic Effects of the Novel Sphingosine Kinase-2 Inhibitor ABC294640. Endocrinology Vol. 151, No. 11, pp. 5124-5135

Srisawat1 P, Streiffer AB, Barbeau DN, Wiese TE, GrimmD, Skaggs BK, Andrew J. Englande J, Reimers RS (2010) Reduction of estrogenic activity in wastewater following treatment with ferrate. Proceedings of the WaterEnvironment Federation Vol. 2010,

Payton-Stewart F, Khupse RS, Boue SM, Elliott S,Zimmermann MC, Skripnikova EV, Ashe H, Tilghman SL, Beckman BS, Cleveland TE,McLachlan JA, Bhatnagar D, Wiese TE, Erhardt P, Burow ME (2010) Glyceollin I enantiomers distinct lyregulate ER-mediated gene expression. SteroidsVol. 75, No. 12, pp. 870-878

Jiang QA, Payton-Stewart F, Elliott S, Driver J,Rhodes LV, Zhang QA, Zheng SL, Bhatnagar D, Boue SM, Collins-Burow BM, Sridhar J, Stevens C, McLachlan JA, Wiese TE, Burow ME, Wang GD (2010) Effects of 7-O Substitutions on Estrogenic and Anti-Estrogenic Activities of Daidze in Analogues in MCF-7 Breast CancerCells. Journal of Medicinal ChemistryVol. 53, No. 16, pp. 6153-6163

Garrison AW, Guillette LJ, Wiese TE, Avants JK (2010) Persistent organochlorine pesticides and their metabolites in alligator livers from Lakes Apopka and Woodruff, Florida,USA. International Journal ofEnvironmental Analytical Chemistry Vol. 90, No. 2, pp. 159-170

Zimmermann MC, Tilghman SL, Boue SM, Salvo VA, ElliottS, Williams KY, Skripnikova EV, Ashe H, Payton-Stewart F, Vanhoy-Rhodes L, Fonseca JP, Corbitt C, Collins-Burow BM, Howell MH, Lacey M, Shih BY,Carter-Wientjes C, Cleveland TE, McLachlan JA, Wiese TE, Beckman BS, Burow ME(2010) Glyceollin I, a Novel Antiestrogenic Phytoalexin Isolated from Activated Soy. Journal of Pharmacology & ExperimentalTherapeutics Vol. 332, No. 1, pp. 35-45

Rees BB, Figueroa YG, Wiese TE, Beckman BS, Schulte PM(2009) A novel hypoxia-response element in the lactate dehydrogenase-B gene of the killifish Fundulus heteroclitus. Comparative Biochemistry & PhysiologyVol. Part A, Molecular & Integrative Physiology. 154, No. 1, pp. 70-77

Boue SM, Tilghman SL, Elliott S, Zimmerman MC,Williams KY, Payton-Stewart F, Miraflor AP, Howell MH, Shih BY, Carter-WientjesCH, Segar C, Beckman BS, Wiese TE, Cleveland TE, McLachlan JA, Burow ME (2009) Identification of the Potent Phytoestrogen Glycinol in Elicited Soybean (Glycine max). Endocrinology Vol. 150, No. 5, pp. 2446-2453

Zhou CH, Nitschke AM, Xiong W, Zhang Q, Tang Y, BlochM, Elliott S, Zhu Y, Bazzone L, Yu D, Weldon CB, Schiff R, McLachlan JA,Beckman BS, Wiese TE, Nephew KP, Shan B, Burow ME, Wang GD (2008) Proteomic analysis of tumor necrosisfactor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediatedepithelial-mesenchymal transition phenotype - art. no. R105. Breast Cancer Research Vol. 10, No. 6,pp. R105

Vu H, Ianosi-Irimie M, Danchuk S, Rabon E, Nogawa T,Kamano Y, Pettit GR, Wiese T, Puschett JB (2006) Resibufogenin corrects hypertension in a rat model of human preeclampsia. Experimental Biology& Medicine Vol. 231, No. 2, pp. 215-220

Boue SM, Wiese TE, Nehls S, Burow ME, Elliott S,Carter-Wientjes CH, Shih BY, McLachlan JA, Cleveland TE (2003) Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. Journal of Agricultural & Food Chemistry Vol. 51, No. 8, pp.2193-9

Coleman KP, Toscano WA, Wiese TE (2003) QSAR Models of the in vitro EstrogenActivity of Bisphenol A Analogs. QuantitativeStructure-Activity Relationships Vol. 22, pp. 78-88

Rubin VN, Ruenitz PC, Boyd JF, Boudinot D, Wiese TE(2002) Characterization of SERM activity in two triairylethylene oxybutyric acids. Biochemical Pharmacology Vol. 63, pp. 1517-1525

Burow ME, Boue SM, Collins-Burow BM, Melnik LI, DuongBN, Carter-Wientjes CH, Li SF, Wiese TE, Cleveland TE, McLachlan JA (2001) Phytochemical glyceollins, isolated fromsoy, mediate antihormonal effects through estrogen receptor alpha and beta.J Clin Endo Metab Vol. 86, No. 4, pp.1750-1758

Walker C, Ahmed SA, Brown T, Ho SM, Hodges L, LucierG, Russo J, Weigel N, Weise T, Vandenbergh J (1999) Species, inter individual, and tissue specificity in endocrine signaling.Environmental Health Perspectives Vol.107, pp. 619-624

Bolger R, Nestich S, Wiese T, Ervin K, Checovich W(1998) Rapid screening of environmental chemicals for estrogen receptor binding capacity. Environ Health Perspect Vol. 106, No. 9, pp. 551-557

Wiese TE, Polin LA, Palomino E, Brooks SC (1997) Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17ß: A 3DQSAR study. J Med Chem Vol. 40,No. 22, pp. 3659-3669

Gray LE, Kelce WR, Wiese T, Tyl R, Gaido K, Cook J,Klinefelter G, Desaulniers D, Wilson E, Zacharewski T, Waller C, Foster P,Laskey J, Reel J, Giesy J, Laws S, McLachlan J, Breslin W, Cooper R, Di GiulioR, Johnson R, Purdy R, Mihaich E, Safe S, Sonnenschein C, Welshons W, Miller R,McMaster S, Colborn T (1997) Endocrine screening methods workshop report: Detection of estrogenic and and rogenichormonal and antihormonal activity for chemicals that act via receptor orsteroidogenic enzyme mechanisms. Reprod Toxicol Vol. 11, No. 5, pp. 719-750

Waller CL, Oprea TI, Chae K, Park H-K, Korach KS, LawsSC, Wiese TE, Kelce WR, Gray LE (1996) Ligand-based identification of environmental estrogens. Chem Res Toxicol Vol. 9, pp. 1240-1248

Wiese TE, Dukes D, Brooks SC (1995) A molecular modeling analysis of diethylstilbestrol conformations and their similarity to estradiol-17beta. Steroids Vol. 60, No. 12, pp. 802-808

Wiese TE, Brooks SC (1994) Molecular modeling of steroidal estrogens:  Novel conformations and their role inbiological activity. J SteroidBiochem Mol Biol Vol. 50, No. 1-2, pp. 61-73

Horwitz JP, Massova I, Wiese TE, Besler BH, Corbett TH(1994) Comparative molecular fieldanalysis of the antitumor activity of 9H-thioxanthen-9-one derivatives againstpancreatic ductal carcinoma 03 [published erratum appears in J Med Chem 1994Sep 16;37(19):3196]. J Med Chem Vol.37, No. 6, pp. 781-6

Horwitz JP, Massova I, Wiese TE, Wozniak AJ, CorbettTH, Sebolt-Leopold JS, Capps DB, Leopold WR (1993) Comparative molecular field analysis of in vitro growth inhibition of L1210 and HCT-8 cells by somepyrazoloacridines. J  Med Chem Vol. 36, No. 23, pp. 3511-6

VanderKuur JA, Wiese T, Brooks SC (1993) Influence of estrogen structure on nuclear binding and progesterone receptor induction by the receptor complex. Biochemistry Vol. 32, No. 27, pp.7002-7008

Wiese TE, Kral LG, Dennis KE, Butler WB, Brooks SC(1992) Optimization of estrogen growth response in MCF-7 cells. In VitroCellular & Developmental Biology Vol. 28A, No. 9-10, pp. 595-602

O'Keefe DH, Wiese TE, Benjamin MR (1987) Effects of mono substituted phenols by the water hyacinth. In: Reddy KR, H. SW (eds) Aquatic Plants for Water Treatment and Resource Recovery. MagnoliaPublishing Inc., pp 505-511

O'Keefe DH, Wiese TE, Brummet SR, Miller TW (1987) Uptake and metabolism of phenolic compounds by the water hyacinth (Eichhorniacrassipes). In: Saunders JA, Kosak-Channing L, Conn EE (eds) Phytochemical Effects of EnvironmentalCompounds. Plenum Publishing Corporation, New York, pp 101-129



LCRC Faculty

Asim Abdel-Mageed DVM PhD
Therapeutics & Diagnostics
Tulane University School of Medicine
Suresh K. Alahari PhD
Therapeutics & Diagnostics
LSU Health - New Orleans
Wayne L. Backes PhD
Tumor Biology
LSU Health - New Orleans
Victoria P. Belancio PhD
Genes & Environment
Tulane University School of Medicine
Earl "Nupsius" Benjamin-Robinson DrHSc CPH
Population Sciences
Louisiana Cancer Research Center
Tom Bishop PhD
Genes & Environment
Louisiana Tech University
David Blask MD PhD
Tumor Biology
Tulane University School of Medicine
Levon Bostanian PhD
Therapeutics & Diagnostics
Xavier University
J. Quincy Brown PhD
Therapeutics & Diagnostics
Tulane University School of Medicine