Development of novel pharmaceutical formulations for the enhanced delivery of small drug molecules.
We arecurrently working on developing novel pharmaceutical formulations to enhancethe delivery of fenretinide, a drug used for the treatment of neuroblastoma inchildren. The project involves developing and in vitro and in vivotesting of the novel formulations.
Education:
B.Sc. Degree in Pharmacy andPharmaceutical Sciences, University of Alexandria, Alexandria, Egypt.
M.S. in Pharmaceutics,University of Alexandria, Alexandria, Egypt.
Ph.D. in Pharmaceutics andPharmaceutical Chemistry, The Ohio State University, Columbus, OH.
ORCID identifier: 0000-0001-8768-7017
MyNCBI Link: https://www.ncbi.nlm.nih.gov/myncbi/levon.bostanian.1/bibliography/public/
Selected Publications:
· T. K. Mandal, L. A. Bostanian, R.A. Graves, S. R. Chapman and I. Womack, “Development of Biodegradable Microcapsules as carrier for Oral Controlled Delivery of Amifostine”, Drug. Dev. Ind. Pharm., 28(3), 339-344, 2002.
· R. A. Graves, S. Pamujula, Moiseyev, T. Freeman, L. A. Bostanian, and T. K. Mandal, “Effect of different ratios of high and low molecular weight PLGA blend on the characteristics ofpentamidine microcapsules”, International Journal of Pharmaceutics; 270(1-2);251-262, 2004.
· S. Pamujula, R. A Graves, R.Moiseyev, L. A. Bostanian, V. Kishore, and T. K. Mandal, “Preparation ofpolylactide-co-glycolide and chitosan hybrid microcapsules of amifostine using coaxial ultrasonic atomizer with solvent evaporation”, Journal of Pharmacy and Pharmacology, 60(3), 283 – 289, 2008.
· S. Pamujula, R. A. Graves, T.Freeman, V. Srinivasan, L. A. Bostanian,V. Kishore, and T. K. Mandal, “Oral Delivery of Spray Dried PLGA/AmifostineNanoparticles”, Journal of Pharmacy and Pharmacology; 56, 1119-1125, 2004.
· G. A. Ledet, R. A. Graves, E. Y. Glotser, T.K. Mandal, and L. A. Bostanian,“Preparation and In Vitro Evaluation of Hydrophilic Fenretinide Nanoparticles”.Int. J. Pharm. 479 (2): 329-337, 2015.
· R. A. Graves, G. A. Ledet, E. Y. Glotser, L. A. Bostanian, and T. K. Mandal, “Formulation and Evaluation of Biodegradable Nanoparticles for the oral delivery of Fenretinide”. Eur. J. Pharm. Sci. 76: 1-9, 2015.
Topics (Keywords/Tags): Nanoparticles, fenretinide, delivery, microcapsules
Link to lab website: https://www.xula.edu/mainresearch/campus-research-projects/rcmi/rcmi-core-laboratories/rcmi-drug-discovery-delivery-core.html
