Dr. Jiri Adamic’s research focuses on taking integrated proteomics, metabolomics, and analytical approaches to identify molecular mechanisms of disease, its biomarkers and develop technologies for their detection and accurate quantification. Particularly interest is in irreversible modifications of proteins and metabolites and their potential interference with cellular processes. These activities include both development of new analytical methods and their application on the specific aging related disease such as cancer, neurodegeneration, and autoimmune disorders. In translational research, we have recently introduced a plasma separation device used to volumetrically collect a plasma aliquot independent of whole blood application volume. This process requires no power and circumvents requirements for venipuncture-phlebotomy training, needles, special vials and equipment, refrigeration, and centrifugation normally associated with traditional plasma methods. The air-dried plasma aliquot can be inexpensively transported with minimal biohazard to a centralized laboratory for quantitation of biomarkers for disease or physiological function.
