The Tobacco Free Living program implements and evaluates comprehensive tobacco control initiatives designed to prevent and reduce tobacco use and also exposure to secondhand smoke. TFL’s successes are largely due to the program’s ability to collaborate with other national, statewide, and local organizations and agencies, while focusing on goals that are supported by a programmatic structure. Local and statewide partnerships, collaboration, and coordination have resulted in community and state-level policy changes that are profoundly impacting tobacco usage and exposure to secondhand smoke in Louisiana. While TFL has seen tremendous progress, much work remains to be done. With thousands of adults dying each year from their own smoking, and another 780 adult nonsmokers dying each year from exposure to secondhand smoke, TFL will allocate resources to strengthen protection from secondhand smoke.